The accident occurred at 12:38 p.m. near Bekasovo 1 station, 37 miles south-west of Moscow, as the passenger train traveled from Moscow to Chisinau, Moldova. The impact caused portions of both trains to derail.
The interior ministry reported five deaths and 25 injuries, although rescue coordinator Vadim Andronov told Russian news agency ITAR-TASS that rescue efforts were still underway and he expected the death toll to rise.
"One of the carriages of the passenger train was crushed by the freight train wagons ... Rescuers are trying to pull out injured people being crushed by the wagon."
There was no information yet available regarding the cause of the train crash.