The United States and Japan established diplomatic relations on March 31, 1854 with the signing of the Treaty of Peace and Amity in modern-day Yokohama.
U.S. Department of State deputy spokesperson Marie Harf recognized the anniversary of the two nations' "remarkable journey together."
"The U.S.-Japan alliance is the cornerstone of peace and security in the Asia-Pacific region, and our partnership drives global economic growth, propels scientific and technological development, and strengthens democracy and development across the world.
"The people of the United States are proud to celebrate our 160-year relationship with the people of Japan. We look forward to even deeper friendship between future generations of U.S. and Japanese citizens."