Prime Minister Nawaz Sharif's adviser Amir Muqam was not injured in the blast, which happened in the Martong area near Poran, Dawn News reported.
Two police officers and four civilians were among those killed, police said.
Muqam was in Martong to settle a dispute between two families and was attacked as he was leaving the area.
The explosives were detonated using a remote device, police said.
Responsibility for the attack has not yet been claimed.
Muqam expressed grief over the loss of life following the attack, as did Sharif, the Express News reported.