Knox and ex-boyfriend Raffaele Sollecito are being retried for the 2007 murder of Kercher in a flat she shared with Knox in Perugia, Italy.
Knox and Sollecito were convicted in 2009 and then acquitted on appeal and released in 2011. Then, in March 2013, the Italian Supreme Court rejected the appeal court's ruling and ordered a retrial.
Since being released from prison, Knox has returned to her home in Seattle where she has remained during recent court proceedings in Italy.
"[If convicted] legally I'll be defined a 'fugitive,' but I will continue to fight for my innocence," Knox said in a statement to "Today" Friday. "I will not willingly submit myself to injustice."
It is unclear whether the United States would extradite Knox if she is reconvicted.