The bus was heading from Cairo to Minya when it crashed into a parked pickup truck near Beba, al-Masry al-Youm reported Monday.
Police said speed and fog in the area were factors in the crash.
The injured were transferred to the Beni Suef General Hospital where Gov. Magdy al-Betity visited them. He vowed to provide them with the support they need.
Notable deaths of 2014 [PHOTOS]