The helicopter's pilot and two division employees were in the aircraft when it went down and broke apart about 150 nautical miles (about 173 miles) from Davis Station as they were returning from surveying a penguin colony, the Australian Broadcasting Corp. reported.
The injured were being assisted by two people from another helicopter that was flying with the one that crashed, officials said.
Rescuers were trying to reach the injured people before weather conditions changed, said Tony Fleming, director of the Kingston-based Australian Antarctic Division, which runs science programs and research projects in Antarctica and the Southern Ocean.
"We are focusing on the recovery operation" Fleming said. "The second helicopter is fine and a couple of the injured employees are taking shelter in that second helicopter."