The quake, which measured 5.6 on the Richter scale, struck Thursday near Borazjan in southern Iran. At least eight people were killed and scores more injured, Iran's Fars news agency reported.
Rosatom, the company that built the nuclear plant in Bushehr, said the quake had no effect on the facility, the Russian news agency RIA Novosti said.
"Despite the earthquake, the plant continues to operate at 100 percent of capacity, the event has no impact on its work. There were no shutdowns or capacity loss," a Rosatom spokesman said.
The earthquake was centered 39 miles northeast of Bushehr, the U.S. Geological Survey reported. The nuclear plant there went on line in 2011.
At least 160 people were injured, 12 critically, Fars said.
Quakes in the 5 range are classified as moderate but can cause heavy damage to poorly constructed buildings.