The explosion occurred inside a nine-story apartment building in the village of Sergiev Posad, RIA Novosti reported.
Police said it was caused by a gas leak.
Eight apartments on the building's top two floors were completely destroyed and some apartments on the seventh floor were damaged, the Emergencies Ministry said. A total of 350 people were inside the building at the time of the explosion.
Police said they were searching the building Monday to make sure no one remained trapped inside.