McCann, a blond haired little girl just days shy of her fourth birthday, disappeared from her parents' villa in Praia da Luz while her parents were eating dinner at a nearby restaurant while they were on vacation from their home in Leicestershire, England, CNN reported Tuesday.
The tips came after a BBC "Crimewatch" broadcast that included new sketches released by police of a man who was seen with a blond girl of about Madeleine's age around the time of the disappearance. At least two of the tipsters said the sketches resembled the same man, Detective Chief Inspector Andy Redwood said.
"There may be an entirely innocent explanation of this man, but we need to establish who he is to assist with our inquiries," Redwood said.
He said police are culling the tips received after the broadcast and prioritizing them before continuing their investigation.
The girl's parents said they remain hopeful their daughter will be found.
"We still worry about her, we miss her as much as we ever did, we remain as determined as ever to find her and to know what has happened," the family said on a website dedicated to their daughter's investigation.