The four children died in the last 48 hours, the Press Trust of India reported.
The disease is running rampant in the state of Uttar Pradesh.
Health officials said 28 people with the disease were admitted to a hospital Monday.
More than 160 patients are being treated in the region's hospitals for encephalitis, and this year, 1,436 patients have been admitted to hospitals with the disease, the Press Trust said.
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