Twelve men and two women were detained during a series of raids, and European and Singapore officials said the alleged "mastermind" also was apprehended, the BBC reported Wednesday.
Nine suspected were released on bail, while five were being detained for additional questioning.
Investigators say they have identified 680 suspicious games between 2008 and 2011, with at least 380 of them in Europe. Some were World Cup qualifiers and European Champions league games.
"Police confirm that the suspected leader and several other individuals who are the subject of ongoing investigations in other jurisdictions for match fixing were among the persons arrested," Singapore police agencies said in a joint statement Wednesday.
Interpol Secretary-General Ronald K Noble said, "Singaporean authorities have taken an important step in cracking down on an international match-fixing syndicate by arresting the main suspects in the case, including the suspected mastermind.''
The Singapore-based cartel allegedly touched players, referees and officials across the globe, the BBC said.
Notable deaths of 2014 [PHOTOS]