"There is no doubt that Jewish communities will continue to stand by Israel, just as Israel will continue to be there for Jewish people everywhere," Netanyahu said Wednesday. "Jewish unity is a major part of our collective strength."
While Israel has made advances in many areas, the country still faces many challenges, notably the Syrian conflict, he said.
Netanyahu stressed that Israel isn't involved in the conflict but would "act with resolve" to protect its people if necessary.
The prime minister also spoke of Iran and its nuclear program that he said threatens Israel, the Middle East and the entire world. Tehran maintains its nuclear program is for civilian purposes while Western countries say they believe it is for development of nuclear weapons capability.
"We cannot allow the world's most dangerous regime to obtain the world's most dangerous weapons," he reiterated. "They must be stopped."
Finally, Netanyahu emphasized the importance of a reaching a lasting peace agreement with Palestinian leaders.
"We want a real, genuine and enduring peace and this must be anchored in recognition of Israel as a Jewish state and in our security," he said. "This is what ultimately is needed."
2014: The Year in Music [PHOTOS]