Personal articles and other memorabilia of Jinnah, who died in 1948, were burned in the attack, Associated Press of Pakistan reported.
Police said four rocket-propelled grenades were fired at the 121-year-old wooden home at Ziarat, about 75 miles outside of Quetta, the provincial capital of Balochistan, National Turk reported.
Six improvised explosive devices found on the property were defused.
The Balochistan Liberation Army has claimed responsibility fore the attack.
In a separate incident, 10 women were killed when a bus exploded at a women-only university in Quetta Saturday.