Three other suspected terrorists were injured when the drone fired three missiles at an al-Qaida convoy in Abyan province, China's official Xinhua news agency reported, citing a local government official who requested anonymity.
Two pickup trucks in the convoy were destroyed, the official said.
The identities of those killed were not yet known, said a second official who confirmed the attack.
Hundreds of militants have been killed in drone strikes since Yemeni President Abd-Rabbu Mansour Hadi took office in February 2012.
A U.S. drone strike hit a civilian home in January, killing two children.