However, residents in Miram Shah told The New York Times, in a telephone interview, that at least four people died and four others were injured in the strike targeting a house in nearby Chashma Pull.
It wasn't known if those killed were militants.
North Waziristan, a tribal region, is seen by U.S. military officials as a haven for militant forces to launch attacks against coalition forces in neighboring Afghanistan.
Last week, U.S. President Barack Obama announced a new drone policy to prevent or limit civilian casualties, although the program has been a major factor in crippling al-Qaida and other militants.
Pakistanis have opposed the program, saying it is a violation of their sovereignty which only helps fan anti-American sentiments.
Nawaz Sharif, who is to become Pakistan's prime minister following his party's victory in May 11 elections, wants an end to the drone program.