Abobker Hamza, Sebha's local council spokesman, said some of the prisoners have either been captured or surrendered to authorities but a large number remain at large since the escape Tuesday, China's state-run Xinhua reported Wednesday.
Hamza said the escape occurred after a dispute among prisoners turned into chaos.
He said local officials have met with the military governor of southern Libya about the incident.
There have been four escapes from the prison during the past two months because of deteriorating security, officials told Xinhua.
Reindeer recovered after escaping from Santa during lighting ceremony
Selena Gomez drops F-bomb, walks off stage during Jingle Ball performance