The explosion in the Damascus suburb of Mazzeh was called a terrorist attack, the state news agency SANA said.
After the bombing, al-Halki attended a government meeting in the capital, Hezbollah's al-Manar television station reported.
No one claimed responsibility for the attack.
Mazzeh in southwest Damascus is located on the Mazzeh highway that leads to a major Syrian air force base and is not far from where the presidential palace is located, CNN said. A number of government and military institutions are located in the area.