The report quoted the sources as saying the compound in Babar Kot's Sararogha village, which was destroyed by missiles fired from the drone, was owned by Tehrik-i-Taliban militants.
China's Xinhua News Agency, quoting local media, reported seven more were injured in the strike in the tribal region.
Wednesday's strike was the second such this month, Xinhua said. On April 4, a suspected drone strike killed four people in a house in North Waziristan.
Rosie O'Donnell unveils nearly 50-pound weight loss
Members of Congress to keep receiving porn magazine