The clashes broke out after a group of Christian teenagers allegedly painted offensive drawings on the gates of a Sunni Muslim institute, Ahram Online reported.
Witnesses said the clashes actually arose from a dispute between a Muslim family and a Christian family.
Police were deployed to the area and arrested 15 people on charges of inciting violence, the state-run Middle Eastern News Agency reported.
There were conflicting reports as to how many people died in the clashes, but Egypt's Health Ministry confirmed five people were fatally shot. Five others were injured, the ministry said.
It was unclear who the gunmen were.