Asmatullah Wazir, an administrator in Jamrud, said the killing was carried out at about 9 a.m. by two men on a motorbike, The Express Tribune reported. The teacher was on her way to the Girls Communal School, an elementary school established by Malik Khanwali.
Khanwali rushed the woman to the Hayatabad Medical Center and notified authorities of the shooting.
"The teacher was rushed to the operating theater for surgery," Wazir said. "However, after three hours of struggle she died."
The Khyber Agency, one of Pakistan's tribal areas on the Afghanistan border, has been the site of several killings targeting female teachers, students and medical workers.