Deputy provincial council leader Abdul Jameh Jameh said the men reportedly ate poisoned food Tuesday, Khaama Press reported. The incident occurred in Gadol.
Gen. Mohammad Hussain, provincial security chief, said an investigation was under way.
No group has claimed responsibility.
Khaama Press said Ghazni is among the most volatile provinces in central-eastern Afghanistan where Taliban militants and other insurgents openly operate.
Jordana Brewster on Paul Walker: 'He was an enormous presence in my life'
Beyonce flaunts bikini body, Blue Ivy in vacation pics