Thirteen unified opposition parties accuse Morsi's regime of repression and brutality and are seeking the "downfall of the regime," officials told the news website Ahram Online.
Khaled Telima, a member of the Popular Current party, told the newspaper Egypt under Morsi has no protection of freedoms or human rights, or sound economic policies.
"Two years after the first victory of the revolution, Egypt's first democratically elected president has set a record for lying and broken promises. Blood was shed yet again and martyrs fell," said a statement from the political parties.
"In the midst of ceaseless political repression, economic and social malaise is worsening day after day ... successive governments have failed to fulfill even one of the demands of social justice."
Among the parties endorsing the rallies were the Social Popular Alliance, the Youth for Justice and Freedom Movement, the Constitution Party, the Popular Movement for the Independence of al-Azhar, the Karama Party, the Free Front for Peaceful Change and the Arab Revolutionary Youth Movement, the website said.