Speaking at the Munich Security Conference, Biden said the United States is ready to meet "bilaterally" with Iranian leaders, CNN reported.
Observing there is a standing offer for talks, the vice president said "there has to be an agenda that they are prepared to speak to. We are not just prepared to do it for the exercise."
Indirect talks with Iran through the five members of the United Nations Security Council and Germany have been stalled for months.
Iran has expressed optimism that incoming U.S. Secretary of State John Kerry will work toward softening Washington's toward Iran.
New U.S. sanctions imposed on Tehran last month targeted companies and individuals the United States says are supplying materials and technology to Iran.
Western nations have put an embargo on purchases of Iranian oil and placed sanctions on the country's banks and many of its businesses.
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