CNN said more than 1,200 police officers were part of the operation.
Officers descended on homes in Croatia, Czech Republic, France, Germany, Greece, Hungary, Poland, Slovak Republic, Turkey and the Kosovo region this week.
CNN said officers recovered $240,000 in cash, in addition to electronics and a gun.
Most of those being smuggled where from Afghanistan, Iraq, Pakistan, Syria and Turkey, CNN said.
The migrants were smuggled in dangerous conditions, often in small hidden compartments, the International Herald Tribune said.
The Tribune said illegal smuggling earns organized groups $3 billion to $10 billion a year.