Scores of people were injured in Tahrir Square in Cairo, where the first protest was held on Jan. 25, 2011, Ahram Online reported. The deaths Friday occurred in Suez
where protesters threw rocks and Molotov cocktails at police.
Al-masry al-Youm newspaper said at least eight people were killed in Suez, including two members of the security forces.
The Health Ministry reported at least 250 injuries across the country, Ahram said.
The 2011 protests began with a gathering of 25,000 people in Tahrir Square and quickly escalated. President Hosni Mubarak, who had ruled Egypt for 30 years, resigned less than three weeks later.
Many demonstrators who turned out after Friday prayers accused President Mohamed Morsi, a longtime member of the Muslim Brotherhood, of being another Mubarak.
"We are protesting against the fact that after two years of the revolution, where we asked for bread, freedom and social justice, none of our dreams have come true," protester Hanna Abu el-Ghar told the BBC.
Participants have demanded retribution for those who died, retrials for those accused of their deaths, ridding the interior ministry of corruption, dismissing Prime Minister Hesham Qandil's Cabinet and Prosecutor General Talaat Abdallah, redrafting the Constitution, setting a minimum and maximum wage, and imposing price controls, the Middle East News Agency reported. Some are calling for the toppling of the current regime.