The clashes, which occurred on Mohamed Mahmoud Street near Tahrir Square, resulted in the deaths of 45 protesters and more than 1,000 injuries, the Egypt Independent reported.
Suspects in the incident were accused of using force against civil servants, arms possession and assaulting policemen who were protecting government buildings.
The Cairo Criminal Court ruled that those to be released fell under a pardon issued by President Mohamed Morsi in October.
Morsi's pardon applies to felony convictions or attempted crimes that were "committed to support the revolution and its goals," until he took office June 30, 2012.
Notable deaths of 2014 [PHOTOS]