The Friday attack targeted a house in the town of Gurbuz, in the border area of North and South Waziristan, Khaama Press reported. The exact target of the strike has not been disclosed.
"The drones fired two missiles on a house believed to be a militant center. Four militants were killed and two injured," a security official said, adding that no senior al-Qaida members or allied jihadist were killed in the attack.
The United States has carried out 46 drone attacks in North Waziristan in 2012, down from 72 strikes in 2011.