The operation, orchestrated from Montreal by the Quebec provincial police force, raided homes and businesses in Quebec, Ontario and British Columbia, The (Montreal) Gazette reported.
Police spokesman Gregory Gomez said the primary target for the predawn sweep was cocaine and other drug trafficking, although eventual charges were likely to expand into other criminal activities.
Various forces, including the Royal Canadian Mounted Police, worked the raids in at least 30 towns and cities in the three provinces, the Gazette said.
There were indications more than one organized crime group was targeted, but details weren't immediately released.
One of the suspects arrested has a known background with the Hells Angels motorcycle gang, the report said.
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