An 82-year-old woman, whose name was not reported, died when she was swept away by floodwaters in the southern Lazio coast town of Gaeta late Wednesday, Italy's ANSA news agency reported.
Her husband survived after he was somehow wedged between a car and a tree, the report said. He was being treated for hypothermia.
In Naples, a 34-year-old man died early Thursday after losing control of his vehicle while driving in the bad weather.
Flooding was reported in southern Lazio Wednesday night, with evacuations reported in the Frosinone area.
The southern region of Campania was battered by strong winds that toppled trees in the Naples area and caused flooding and evacuations near Salerno.
In the north, high water was reported in and around Venice.