It was the first such incident since a weekend protest, led by Imran Khan, Pakistan's popular cricketer-turned-politician, against drone attacks.
Two Pakistani intelligence officials told CNN four missiles were fired at the suspected militant hideout in the Mir Ali area of North Waziristan, which U.S. officials have said serves as a hideout for militant groups to launch attacks on U.S. and NATO forces in neighboring Afghanistan.
It wasn't reported who was killed in the attack.
There has been much criticism of the drone strike program in Pakistan, whose officials maintain the strikes also kill civilians.
In the Khan-led protest, the participants, including activists from the United States and Britain, marched to the border the tribal region, CNN reported. The march was stopped by Pakistani authorities.
Khan has said the drone strikes are a violation of Pakistan's sovereignty.