The al-Qaida operatives were identified as Turkish origin Seleh al-Turki and Abu Akash al-Iraqi, an Iraqi, but the report said both names were aliases.
The drone strike Monday in the Mir Ali area of North Waziristan, which U.S. officials have said is a haven for leaders of terror groups, also killed three others, the report said.
Al-Turki was a field operative associated with al-Qaida. "He was not on the (U.S. Federal Bureau of Investigations') bounty list, but was a midlevel A.Q. guy," the official told the Times.
Al-Iraqi, who had long been sought by Western counter-terrorism agencies, had been living in Pakistan's border regions for 15 years, having married the daughter of a local tribal cleric, the Times said.
The Long War Journal was quoted as describing him as an important link between al-Qaida and the Taliban.
The other three killed in the drone strike also were foreign militants, the official told the Times.
Pakistan's Daily Times quoted a Pakistani intelligence source telling a local TV channel al-Iraqi had arrived in North Waziristan Agency in 2001. The report said Taliban sources also confirmed al-Iraqi and al-Turki's funerals were held in the Mosaki area of North Waziristan Monday night.