A court mandate ruled the settlers must leave the outpost by Tuesday, though security forces knocked on doors Sunday morning, telling families they must leave that day, The Jerusalem Post reported.
"The residents of Migron feel betrayed and pained by this move, and protest the miserable, unnecessary devastation about to happen here," a statement from the settlers said.
Most residents left the settlement peacefully to move into temporary housing about 1.5 miles away in Ofra, Haaretz reported. A few activist teens barricaded themselves on the roof of a caravan and refused to leave.
Negotiations between residents of Migron and the government have been ongoing for years. The settlers said they bought the land legally from private Palestinian landowners.
A panel of justices ruled the legitimacy of the transactions could not be proven, Haaretz reported.
"The purchasers have nothing more than a purchase," the ruling said.