Women were prominent in the group that gathered Friday, Egypt Independent reported. The protesters called on the Brotherhood to either dissolve or to become a non-political charitable group.
"The Brotherhood wants to control the country entirely," said Nesrine Mohamed, 31, who said she voted against President Mohamed Morsi. "They have suppressed all voices of dissent."
While Morsi was not formally the Brotherhood candidate, he was generally perceived as representing the group.
Some political activists said Friday's demonstration did not represent their views and described turnout as low because most of the potential opposition to Morsi stayed home, Avram Online reported. Haitham el-Shawaf, general coordinator of the Alliance of the Revolutionary Forces, charged the protest was arranged by supporters of Egypt's longtime military rulers.
"We will judge Morsi's promises at the end of the 100 days he asked for," he said.
Salma Said, an activist, agreed.
"There is a difference between those opposing the Muslim Brotherhood to replace it with the old regime, and with those who want neither," she said.