One service member died Saturday in an insurgent attack, ISAF said in a statement.
On Sunday, two service members died in a road accident in the region. A service member also died as a result of a non-battle-related injury in western Afghanistan.
At least 209 NATO services members have been killed in Afghanistan since the beginning of 2012, Khaama Press reported.
Charlize Theron not engaged to Sean Penn 'yet'
Pregnant Mila Kunis wins 'Best Villain' at MTV Movie Awards