The Cairo Criminal Court found Azmy guilty of using his position to generate illicit gains of more than $7 million in money and other goods, al-Masry al-Youm reported.
The court sentenced Azmy to seven years in prison and ordered him to pay a fine of nearly $6 million.
Azmy's wife, Baheya Halawa, was also ordered to repay the illicit gains she acquired while her husband was in office.
Halawa's brother, businessman Gamal Halawa, has been sentenced to one year of hard labor.
Azmy, who was arrested in April on corruption charges, served as ousted President Hosni Mubarak's chief of staff for 22 year. He is one of several members of the former president's staff accused of amassing wealth at the expense of ordinary Egyptians.