Hina Rabbani Khar said Monday any credible intelligence on Zawahiri's possible presence in the country is needed so Pakistani officials can investigate, The Express Tribune reported.
Khar spoke about intelligence-sharing during a speech before Parliament and responded to remarks by U.S. Secretary of State Hillary Clinton in India.
Dawn reported that Clinton said: "There are several significant leaders still on the run. Zawahiri, who inherited the leadership from bin Laden is somewhere, we believe, in Pakistan."
Clinton said talks between Pakistan and the United States were continuing and indications they were halted were erroneous.
Khar said he was hopeful the United States would respect the Pakistani Parliament's recommendations concerning discussions about the reopening of NATO supply routes through Pakistan to Afghanistan.
The Parliament last month unanimously passed a resolution that set new terms and conditions for reopening the supply routes, linking the reopening to the end U.S. drone strikes.
Pakistan condemned a recent drone attack in North Waziristan, saying it violated international law.
The United States said it would conduct drone strikes against militants hiding out in the tribal regions along the Pakistan-Afghanistan border, despite the Pakistani government's opposition.