The vehicle was destroyed, sources told the Iranian Islamic Republic News Agency. The U.S. drone fired two missiles.
The attack took place in the Data Khel region of North Waziristan, a tribal area officials say is a sanctuary for Taliban and al-Qaida fighters.
The drone strike was the third since Osama bin Laden was killed early this month in a U.S. raid on his compound in Abbotabad, north of Islamabad. More than 200 people are believed to have been killed in 28 attacks by unmanned U.S. aircraft this year.