The pursuit began around 2 a.m. Officers responding to a report of gunfire at 53rd and Figueroa streets in South Los Angeles found a wounded man in his 20s lying in the street and three men getting into a minivan.
Police chased the van down the 110 Freeway. It crashed near Los Angeles International Airport, and two men tried to escape on foot.
The pair and a third man in the minivan were arrested and taken to a hospital for examination, KTLA-TV reported. The gunshot victim died after being transferred to a hospital.
The Los Angeles Times Homicide Report said the area where the shooting occurred is a violent one. Eleven homicides have been reported within a mile of 53rd and Figueroa in the past year.