Some 104 vehicles were involved in the pileups that took place as snow fell on the area, the Denver Post reported.
The accidents caused the northbound stretch of the interstate to be closed for five hours and traffic was at a complete stop for more than a mile behind the crash.
Four people were taken to St. Anthony Hospital, 14 to Denver Health Medical Center and 12 to Swedish Medical Center, Denver Health reported on Twitter.
Denver Paramedics report 30 people transported from today's pileup on i25. 14 to @DenverHealthMed 4 to St a's 12 to Swedish— Denver Health Med. (@DenverHealthMed) March 1, 2014
"People were just driving too fast for conditions," said Darrell Barber, who was involved in the crashes. "It was totally preventable."