Patrick told Politico he would consider a presidential campaign sometime after 2016, provided his wife agreed.
"That's a decision I have to make along with my wife of 30 years and she's a tough one to convince," Patrick said.
Patrick is midway through his second term in office and has ruled out running for a third in 2016. Instead, he plans to return to the private sector, where he was a lucrative corporate attorney before running for and winning the Bay State's top job in 2008.
He has ruled out a potential 2016 presidential run, but he said that might not always be the case.
"I'd like to have another opportunity to serve. I believe in service. I enjoy it," the governor said. "I also like coming and going, you know, because I think that my private-sector life has contributed to how I think about public-sector challenges and what I do in the public sector."