Sky's win Tuesday was the second recent Best-in-Show victory for handler Gabriel Rangel, who led a Scottish terrier named Sadie to the title in 2010, the New York Times reported.
Ally, a standard poodle, was runner-up.
But it was a bloodhound named Nathan that stole the crowd. His fans cheered whenever a camera or judge came near him, the Times said.
Best in Show Judge Betty Regina Leininger said Sky's performance was astonishing.
"She just said, 'Pick me,'" she said during a news conference with Sky and Rangel. "She is a beautiful wire. She really made us proud."
"This was her night. I've seen her before. I had never judged her before," Leininger said. "I had seen her before at other dog shows where she's won. She looked the best tonight from every angle."
Rangel said Sky was "the little perfect dog" who seems to know what to do when it counts.
"You put the lead on her, she puts the tail up." He said. "You put food in your pocket, and she's like, 'What do you want me to do?'"