The U.S. Department of the Treasury said the targets, operating in Europe and the Middle East, will be barred from access to the U.S. financial system.
The companies and individuals singled out Thursday were described as operating outside the various sanctions that were eased this year when negotiations over the controversial Iranian nuclear program were agreed to, the department said in a written statement.
"The global targets designated today play key roles in supporting Iran's nuclear program and active support for terrorism," said Under Secretary for Terrorism and Financial Intelligence David Cohen. "The United States has made clear that as it implements the Joint Plan of Action, contingent on Iran satisfying its own commitments, the overwhelming majority of sanctions remain in effect and will continue to be vigorously enforced."
The targets listed allegedly controlled companies involved in providing Iran with military technology, or financial institutions and companies that helped Iran dodge financial sanctions.