Bush, 88, wife of former President George H.W. Bush, was admitted to Methodist Hospital Monday because of respiratory problems.
She was discharged Saturday, the Houston Chronicle reported.
"I cannot thank the doctors and nurses at Houston Methodist enough for making sure I got the best treatment and got back to George and our dogs as quickly as possible," she said.
Barbara Bush was diagnosed in 1988 with Graves' disease, an autoimmune disorder, and was treated in 2010 when the disease flared up.
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