Police in Raton found the four teenagers on Saturday and arrested them after a short chase on foot, KMGH-TV, Denver, reported.
Brenna Gomez, 15, her 16-year-old boyfriend, Spencer Linville, and two other unidentified teenagers left Wisconsin in a stolen car on Monday night, police said.
Sheriff's deputies spotted them in Colorado late Thursday and attempted to pull them over.
But the teens fled and traveled 100 mph to elude authorities, the report said.
Later that night, the stolen car was found abandoned, and another vehicle was reported stolen.
Authorities then issued an alert for Gomez, who is a diabetic and left her insulin in the abandoned car.
Her family said that they are relieved that Gomez, who is susceptible to seizures without her medication, was found.
"I'm not proud of what they did or anything else, especially Breanna. She's our granddaughter. I'm just glad she's safe, and I know that she's going to have to pay for the things she has done. There's no excuse," Judy Carpenter, Gomez's grandmother, said.
Jerry Carpenter, Gomez's grandfather, said the 15-year-old was recently released from juvenile detention.
Morgan County, Colo., authorities said the teenagers will likely be charged with felony possession of stolen property, vehicular eluding and menacing.