About 100 residents remained evacuated from their homes as fire crews from around the state battled the blaze, NBC News reported Wednesday.
The fire, which broke out Sunday night, is being fueled by low humidity and warm temperatures.
Officials said they hope a rise in humidity will help them contain the fire by Friday.
The fire destroyed 22 buildings, including 14 homes, one of which belonged to Big Sur's fire chief, NBC News said.
One person suffered minor injuries in a fall related to the fire Wednesday, and was treated at and released from a hospital.
Weather officials expected wind gusts at high as 30 mph to cause difficulty fighting the fire.