"I don't think you can tell what will happen next year," Pelosi, who appeared on NBC's "Meet the Press," said. "I will tell you this: Democrats stand tall in support of the Affordable Care Act."
She argued that jobs, and not Obamacare, will be the major issue in the campaigns, and said that politicians and residents must be patient with the program and website.
"What I love about healthcare professionals is that they're calm. And we must remain calm when we talk about the health of our country," she said. "You can't be knocked for a loop just because somebody is playing politics."
Her comments come after 39 House Democrats voted for a Republican bill that would allow health insurance firms to sell insurance plans that don't comply with the Affordable Care Act requirements.
Pelosi was asked about that vote Sunday.
"When the Republicans put forth a political initiative, people respond to it politically," she said.