Traffic resumed in the lanes on Interstate 710 in Commerce about 5 a.m., nearly 20 hours after the accident, which injured two men and set fire to six other vehicles, the San Gabriel Valley Tribune in West Covina reported.
No homes were reported damaged.
Both sides of the highway were closed Sunday after the tanker truck hit an overpass guardrail, caught fire and dumped blazing fuel onto the highway below, the San Gabriel Valley Tribune in West Covina reported.
The northbound lanes of the freeway were closed for about an hour.
The driver of the truck and a man walking nearby received minor to moderate injuries, Los Angeles County Fire Department Inspector Brian Jordan said.
A California Highway Patrol incident log indicated the truck driver may have lost control of the rig because of a blowout, the Los Angeles Times reported.