The bus, bound for Cleveland from New York City, was traveling on Interstate 80 when it hit the back end of a truck hauling garbage on a trailer, The (Cleveland) Plain Dealer reported.
More than 40 people were injured in the 1:30 a.m. crash in Union County, said Pennsylvania State Trooper Matthew Burrows.
The driver of the tractor-trailer was not injured, but the bus driver was "seeking medical attention," Burrows said.
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