Clinton, 33, who married her longtime boyfriend Marc Mezvinsky in 2010, said 2014 has been dubbed "the year of the baby" in an interview in the November issue of Glamour magazine.
"We want, God willing, to start a family. So we decided we were going to make 2014 the year of the baby," she said. "And please, call my mother and tell her that. She asks us about it every single day."
Clinton said she and her husband made the decision to have children in the wake of her grandmother's death in 2011. Clinton said she was extremely close with her grandmother, Dorothy Rodham, Hillary Rodham Clinton's mother. The death forced her to re-examine her priorities in life -- and starting a family was high on the list.
"It was such a fundamentally unmooring event for me," Clinton said. "I've never been so lost as I was when she passed. ... [Marc and I] sat down and said, 'Here's what we want to do.' The first thing on the list was simple: We want, God willing, to start a family."