Officials said power lines were knocked down but no hazardous materials were released when the accident occurred near the intersection of two roads east of Amarillo, the Amarillo Globe-News reported.
An eastbound train was stopped on the tracks when it was hit from behind by another train traveling in the same direction, said Joe Faust, a spokesman for Burlington Northern Santa Fe Railway.
The collision caused about 20 to 30 cars on the trains to derail, and those cars were hit by a westbound train a short time later.
Four people were taken to local hospitals with non-life threatening injuries, said Department of Public Safety spokesman Chris Ray. He did not indicate how they were injured.
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